This week’s newsletter covers Uruguay’s landmark move to integrate CBD into its national healthcare system, a historical review of endocannabinoid science, and the latest research on CBD’s potential for Alzheimer’s disease, skin conditions, and chronic back pain.
Noteworthy Read
Uruguay Includes CBD in Healthcare System (Sechat)
Uruguay’s government has announced its intention to add cannabidiol (CBD) to the national therapeutic formulary, expand access to cannabis-based therapies, and improve adult-use regulation to reduce reliance on the informal market.
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More Noteworthy Reading
Endocannabinoid Research Timeline (Project CBD) — by Nate Seltenrich
This timeline walks through the key discoveries that shaped modern cannabinoid science — from identifying THC and CBD in the 1960s to uncovering the body’s own cannabinoid receptors and signaling molecules like anandamide and 2-AG. It highlights how researchers came to understand the endocannabinoid system as a major regulator of health and balance.
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Research Round-Up
Exploring CBD’s Therapeutic Potential for Alzheimer’s (EurekAlert!)
Emerging preclinical and early-phase human research reveals that CBD may help reduce neuroinflammation, oxidative stress, and amyloid plaque formation, suggesting a possible adjunct role in Alzheimer’s disease therapy.
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How Does Cannabis Help Skin Conditions? (Cannabis Science & Technology)
This article reviews mechanisms by which cannabinoids and cannabis-derived compounds may benefit skin health—via anti-inflammatory, sebum-regulating, and barrier-supporting pathways—and discusses topical formulations and clinical evidence.
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A Drug Made from Cannabis Reduced Back Pain in a Large Study (The Hill / AP)
In a Phase 3 trial involving 800 patients, a cannabis-derived extract (VER-01) produced about a 2-point pain reduction on an 11-point scale vs placebo, also improving sleep and physical function with fewer serious safety concerns than opioids.
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A heartfelt thank you to all of the CBD brands whose generous support makes it possible for Project CBD to shine a light on the plant medicine research and stories that matter most. We’re grateful for every one of you.
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